Figure 4. Impaired behavioral deficits in high fat fed 3xTg-AD mice.

A, Spontaneous alternation behavior (SAB) in the Y-maze in standard and high fat fed male and female 3xTg-AD mice. B, Object recognition performance in standard and high fat fed female 3xTg-AD mice at 2 and 18 hrs after training (2 and 18 hr probe). *p<0.001 relative to matched sex with standard diet. Data presented as mean ± SEM. *p<0.001 relative to matched sex with standard diet. † p<0.001 relative to matched probe trial.