Table III.
Nucleotide variant | Amino acid change | Allele frequency in BC | Allele frequency in controls | P-value | PoliPhen/SIFT/phylogenetic conservation of IRS-1 wild-type residue | BC patient code |
---|---|---|---|---|---|---|
c.798C>T | p.Arg267Cys | 1/24 | 0/94 | 0.047 | Probably damaging/intolerant/complete | MDA-MB-365 |
IRS, insulin receptor substrate; BC, breast cancer.