Table III.

Novel IRS-1 variant in breast cancer.

Nucleotide variant	Amino acid change	Allele frequency in BC	Allele frequency in controls	P-value	PoliPhen/SIFT/phylogenetic conservation of IRS-1 wild-type residue	BC patient code
c.798C>T	p.Arg267Cys	1/24	0/94	0.047	Probably damaging/intolerant/complete	MDA-MB-365

IRS, insulin receptor substrate; BC, breast cancer.