Table IV.
Common IRS-1 and IRS-2 variants in breast cancer.
| Nucleotide variant | Amino acid change | Allele frequency in BC | Allele frequency in controls | P-value |
|---|---|---|---|---|
| IRS-1 | ||||
| c.702G>A | p.(=) | 1/24 | 8/94 | NS |
| c.2678G>C | p.(=) | 3/24 | 0/94 | 0.0005 |
| IRS-2 | ||||
| c.2169C>T | p.(=) | 16/22 | 105/316 | 0.0002 |
| c.2448T>C | p.(=) | 11/22 | 105/296 | NS |
| c.2487C>T | p.(=) | 2/22 | 70/208 | NS |
| c.2635G>A | p.Gly879Ser | 1/22 | 3/200 | NS |
| c.2645G>C | p.Gly882Ala | 1/22 | 0/50 | NS |
| c.3171G>A | p.Gly1057Asp | 6/22 | 244/798 | NS |
IRS, insulin receptor substrate; BC, breast cancer; NS, not significant.