Skip to main content
. 2013 Jul 18;30(4):1553–1560. doi: 10.3892/or.2013.2626

Table VII.

Common IRS-1 and IRS-2 variants in colorectal cancer.

Nucleotide variant Amino acid change Allele frequency in CRC patients Allele frequency in controls P-value
IRS-1
 c.270C>T p.(=) 2/94 3/94 NS
 c.702G>A p.(=) 2/94 8/94 NS
 c.2412A>G p.(=) 12/94 12/94 NS
 c.2452G>C p.Gly818Arg 1/94 2/94 NS
 c.2911G>A p.Gly971Arg 3/94 8/94 NS
 c.3056T>C p.Ile1019Thr 1/94 0/94 NS
 c.3334C>T p.Arg1112Trp 1/94 0/94 NS
 c.3388G>A p.Gly1130Ser 1/94 0/94 NS
 c.3489A>C p.(=) 1/94 0/94 NS
 c.3606C>T p.(=) 1/94 0/94 NS
IRS-2
 c.2169C>T p.(=) 45/90 105/316 0.004
 c.2448T>C p.(=) 53/90 105/296 <0.001
 c.2487C>T p.(=) 22/90 70/208 NS
 c.2635G>A p.Gly879Ser 1/90 3/546a NS
 c.2645G>C p.Gly882Ala 1/90 0/396a 0.036
 c.2673G>C p.(=) 8/90 ND ND
 c.3093G>A p.(=) 1/90 0/50 NS
 c.3099A>G p.(=) 27/90 ND ND
 c.3171G>A p.Gly1057Asp 27/90 244/798 NS
 c.3730T>C p.Ser1244Pro 1/90 0/396a 0.036
 c.3788G>T p.Gly1263Val 1/90 0/396a 0.036
a

Controls including samples analyzed in our laboratory plus 173 controls in Bottomley et al(17).

IRS, insulin receptor substrate; CRC, colorectal cancer; NS, not significant; ND, not determined.