Table VII.

Common IRS-1 and IRS-2 variants in colorectal cancer.

Nucleotide variant	Amino acid change	Allele frequency in CRC patients	Allele frequency in controls	P-value
IRS-1
c.270C>T	p.(=)	2/94	3/94	NS
c.702G>A	p.(=)	2/94	8/94	NS
c.2412A>G	p.(=)	12/94	12/94	NS
c.2452G>C	p.Gly818Arg	1/94	2/94	NS
c.2911G>A	p.Gly971Arg	3/94	8/94	NS
c.3056T>C	p.Ile1019Thr	1/94	0/94	NS
c.3334C>T	p.Arg1112Trp	1/94	0/94	NS
c.3388G>A	p.Gly1130Ser	1/94	0/94	NS
c.3489A>C	p.(=)	1/94	0/94	NS
c.3606C>T	p.(=)	1/94	0/94	NS
IRS-2
c.2169C>T	p.(=)	45/90	105/316	0.004
c.2448T>C	p.(=)	53/90	105/296	<0.001
c.2487C>T	p.(=)	22/90	70/208	NS
c.2635G>A	p.Gly879Ser	1/90	3/546a	NS
c.2645G>C	p.Gly882Ala	1/90	0/396a	0.036
c.2673G>C	p.(=)	8/90	ND	ND
c.3093G>A	p.(=)	1/90	0/50	NS
c.3099A>G	p.(=)	27/90	ND	ND
c.3171G>A	p.Gly1057Asp	27/90	244/798	NS
c.3730T>C	p.Ser1244Pro	1/90	0/396a	0.036
c.3788G>T	p.Gly1263Val	1/90	0/396a	0.036

^aControls including samples analyzed in our laboratory plus 173 controls in Bottomley et al(17).

IRS, insulin receptor substrate; CRC, colorectal cancer; NS, not significant; ND, not determined.