Figure 7. TPZ mediates damage to endothelial tube structures in a concentration, time and oxygen dependent manner.

HMECs seeded onto Matrigel-coated plates formed tubular structures by 24 h and were then treated with TPZ in (A) 2% or (B) 0.2% oxygen conditions for indicated times. Whole wells (top; scale bars 500 µm) and magnified representative areas (bottom; scale bars 150 µm) are shown.