Table 2.

Minimum inhibitory concentrations for isavuconazole, for 50% and 90% (MIC₅₀ and MIC₉₀, respectively) of Candida spp. isolates.¹⁸

Pathogen	Antifungal agent	MIC50 (μg/mL)	MIC90 (μg/mL)
Candida albicans	Isavuconazole	<0.002–0.03	<0.002–0.03
	Voriconazole	<0.016–0.03	0.03–0.06
	Caspofungin	0.03–0.5	0.03–1
	Amphotericin B	0.25–0.5	0.5–1
Candida glabrata	Isavuconazole	0.25–2	0.5–8
	Voriconazole	0.125–1	1–4
	Caspofungin	0.125	0.125–0.25
	Amphotericin B	0.5–2	0.5–2
Candida krusei	Isavuconazole	0.125–0.5	0.25–1
	Voriconazole	0.25–0.5	1–4
	Caspofungin	0.25	0.25–0.5
	Amphotericin B	0.5–2	0.5–4
Candida parapsilosis	Isavuconazole	<0.015–0.03	0.03–0.125
	Voriconazole	<0.015–0.6	0.06–0.125
	Caspofungin	0.25	1–2
	Amphotericin B	0.25–1	0.5–2
Candida tropicalis	Isavuconazole	<0.015–0.03	0.03–0.125
	Voriconazole	0.03–0.125	0.06–2
	Caspofungin	0.125–0.25	0.5
	Amphotericin B	0.5–2	0.5–2

Note: Copyright © 2010, Springer Science and Business Media. Adapted with permission from Thompson GR III, Wiederhold NP. Isavuconazole: a comprehensive review of spectrum of activity of a new triazole. Mycopathologia. 2010;170(5):291–313.¹⁸

Abbreviation: MIC, minimum inhibitory concentration.