Table 3.

Minimum inhibitory concentrations of isavuconazole and selected antifungal agents for 50% and 90% (MIC₅₀ and MIC₉₀, respectively) of Aspergillus spp. isolates.¹⁸

Pathogen	Antifungal agent	MIC50 (μg/mL)	MIC90 (μg/mL)
Aspergillus fumigatus	Isavuconazole	0.25–1	0.5–2
	Voriconazole	0.25–1	0.5–2
	Caspofungin	0.06–0.5	0.06–0.5
	Amphotericin B	0.25–4	0.5–8
Aspergillus terreus	Isavuconazole	0.5–1	0.5–4
	Voriconazole	0.25–1	0.5–2
	Caspofungin	0.03–0.5	0.06–0.5
	Amphotericin B	1–4	1–8
Aspergillus flavus	Isavuconazole	0.5–2	1–16
	Voriconazole	0.5–1	0.5–2
	Caspofungin	0.03–0.25	0.03–0.25
	Amphotericin B	1–2	1–4
Aspergillus niger	Isavuconazole	0.5–2	2–4
	Voriconazole	0.25–2	1–2
	Caspofungin	0.06–0.25	0.125–0.25
	Amphotericin B	0.5–1	0.5–2

Note: Copyright © 2010, Springer Science and Business Media. Adapted with permission from Thompson GR III, Wiederhold NP. Isavuconazole: a comprehensive review of spectrum of activity of a new triazole. Mycopathologia. 2010;170(5):291–313.¹⁸

Abbreviation: MIC, minimum inhibitory concentration.