Figure 10.

Effects of BNC on expression of ERK1/2, p-ERK1/2, PARP, and caspase-3 in H9c2 cells treated with H₂O₂ (a) and effects of BNC on expression of ERK1/2 and p-ERK1/2 in the presence of ERK1/2 inhibitor, PD98059 (10 μM) (b). Protein expression was detected by western blot analysis. The ratio of p-ERK1/2/ERK1/2 significantly increased in response to BNC pretreatment (c). Values are expressed as mean ± SD from three independent experiments. **P < 0.01 versus control; *P < 0.05 versus control; ^## P < 0.01 versus model.