Table 2.
Results of clinical assessments in the overall population over time
| Assessment | Baseline (N = 67)
|
4 wk (n = 65)
|
3 mo (n = 52)
|
6 mo (n = 48)
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| n | Mean (SD) | n | Mean (SD) | P-value (95% CI)* | n | Mean (SD) | P-value (95% CI)* | n | Mean (SD) | P-value (95% CI)* | |
| T25FW | |||||||||||
| Time, sec | 54 | 13.9 (8.9) | 53 | 12.2 (10.0) | P < 0.03 (9.4, 15.0) | 40 | 9.7 (6.0) | P < 0.0001 (7.8, 11.6) | 35 | 10.4 (7.9) | P < 0.001 (7.7, 13.1) |
| Speed, m/sec | 54 | 0.55 (0.86) | 53 | 0.62 (0.76) | P < 0.0001 (0.58, 0.83) | 40 | 0.79 (1.27) | P < 0.0001 (0.72, 1.03) | 35 | 0.73 (0.95) | P < 0.0001 (0.69, 0.97) |
| MSWS-12 score | 67 | 77 (19) | 64 | 66 (20) | P < 0.0001 (61, 71) | 52 | 64 (20) | P < 0.01 (58.3, 69.7) | 44 | 66 (23) | P < 0.0001 (59, 73) |
| EQ-5D score | 66 | 1.7 (0.3) | 64 | 1.6 (0.3) | P < 0.001 (1.6, 1.7) | 51 | 1.7 (0.3) | P < 0.01 (1.6, 1.8) | 46 | 1.6 (0.3) | P < 0.001 (1.5, 1.7) |
| FSS score | 38 | 5.2 (1.4) | 36 | 4.7 (1.5) | P < 0.06 (4.2, 5.2) | 30 | 4.2 (1.5) | P < 0.01 (3.7, 4.8) | 26 | 4.2 (1.4) | P < 0.01 (3.6, 4.7) |
Notes:
*
Statistical analyses (P-values and 95% CIs) refer to group difference between baseline and the respective follow-up visit. Statistical significance was defined as P < 0.05.
Abbreviations: CI, confidence interval; EQ-5D, EuroQoL-5D descriptive system; FSS, Fatigue Severity Scale; mo, month; MSWS-12, 12-item Multiple Sclerosis Walking Scale; SD, standard deviation; sec, second; T25FW, Timed 25-Foot Walk; wk, week.