Table 2.
Baseline
|
Week 12 (n = 38)
|
Week 24 (n = 36)
|
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Mean | SD | Mean | SD | Mean difference from baseline | P valuea | Mean | SD | Mean difference from baseline | P valuea | |
WOMAC—hips/knees | ||||||||||
Function (0–100) | 38.2 | 27.5 | 27.5 | 22.1 | −10.7 | 0.01 | 24.9 | 21.4 | −13.3 | 0.004 |
Pain (0–100) | 37.0 | 26.9 | 27.4 | 22.7 | −9.6 | 0.03 | 28.4 | 24.4 | −10.7 | 0.02 |
Stiffness (0–100) | 37.8 | 30.9 | 28.8 | 28.5 | −9.0 | 0.10 | 30.9 | 29.5 | −7.5 | 0.15 |
M-SACRAH—hand/wrists | ||||||||||
Function (0–100) | 29.9 | 26.0 | 20.7 | 22.4 | −9.2 | 0.03 | 22.1 | 23.1 | −8.5 | 0.02 |
Pain (0–100) | 48.1 | 28.3 | 33.7 | 23.7 | −14.4 | 0.0011 | 34.6 | 24.5 | −13.8 | 0.0008 |
Stiffness (0–100) | 52.1 | 30.1 | 40.8 | 26.1 | −11.3 | 0.03 | 44.6 | 27.0 | −7.9 | 0.13 |
BPI | ||||||||||
Pain severity (0–10) | 4.9 | 2.2 | 4.2 | 2.1 | −0.7 | 0.05 | 4.3 | 2.0 | −0.6 | 0.07 |
Pain interference (0– 10) | 4.1 | 2.3 | 3.5 | 2.2 | −0.6 | 0.06 | 3.2 | 2.2 | −1.0 | 0.0003 |
Worst pain (0–10) | 6.2 | 2.3 | 5.3 | 2.5 | −0.9 | 0.02 | 5.3 | 2.6 | −1.2 | 0.02 |
Grip strength (kPAs) | ||||||||||
Pinch grip strength | ||||||||||
Right hand | 31.3 | 10.6 | 33.8 | 8.7 | 2.5 | 0.07 | 32.2 | 9.6 | 2.0 | 0.22 |
Left hand | 28.6 | 9.1 | 31.2 | 8.1 | 2.6 | 0.02 | 28.9 | 8.5 | 1.5 | 0.22 |
Tripod grip strength | ||||||||||
Right hand | 34.1 | 11.0 | 37.9 | 9.9 | 3.8 | 0.02 | 35.6 | 9.6 | 2.7 | 0.06 |
Left hand | 33.2 | 10.3 | 37.2 | 10.3 | 4.1 | 0.02 | 35.3 | 9.9 | 2.8 | 0.11 |
Power grip strength | ||||||||||
Right hand | 37.7 | 12.9 | 42.6 | 11.9 | 4.9 | 0.01 | 41.8 | 11.6 | 3.9 | 0.0005 |
Left hand | 35.9 | 11.7 | 40.6 | 11.5 | 4.6 | 0.02 | 39.2 | 10.7 | 4.3 | 0.02 |
FACT | ||||||||||
Functional well-being | 18.8 | 5.7 | 22.6 | 6.7 | 3.8 | 0.0001 | 18.1 | 6.0 | −0.2 | 0.79 |
Physical well-being | 17.8 | 5.4 | 19.2 | 5.4 | 1.4 | 0.14 | 18.4 | 5.3 | 1.0 | 0.16 |
Endocrine well-being | 52.0 | 11.5 | 54.1 | 9.8 | 2.1 | 0.09 | 50.9 | 10.7 | −1.2 | 0.36 |
WOMAC Western Ontario and McMaster Universities Osteoarthritis Index, M-SACRAH Modified Score for the Assessment and Quantification of Chronic Rheumatoid Affections of the Hands, BPI Brief Pain Inventory, FACT Functional Assessment of Cancer Therapy, kPAs kilopascals
P values calculated using paired t tests to compare differences in group means at baseline and follow-up