Table 3. Important Characteristics for biodosimetry methods to be used after an IND incident.
Characteristic | Reason |
---|---|
Simple sample collection method | Requires fewer specially trained personnel |
Field-readiness | Samples can be run on site, little sample preparation required |
Short time to result | Results can be used to guide treatment more quickly |
High-capacity | A large number of samples can be run on one instrument |
Time to result | Medical care can begin earlier with a fast time to result |
Dual-utility | Method in routine use, return on investment, personnel will be trained and used to performing test |
Method standardization | Ease of comparing results across laboratories, systematic training |
Specificity for radiation | Low background signal, not affected by confounders such as inflammation or infection |
Low inter-individual variation | Baseline would not need to be determined for each segment of the population (e.g. age, gender) |
Low intra-individual variation | Decreased need for repeated tests, test not confounded by infection or other medical treatments |
Low uncertainty in the result | Decreased need for repeated tests |
Stable output signal | Increases the amount of time the assay can be used |
Inexpensive sample processing | Number of tests required will be large and cost will add up quickly |