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. 2013 Oct 29;4:168. doi: 10.3389/fneur.2013.00168

Figure 2.

Figure 2

Changes in mechanical sensitivity (top set) in male and female Lewis rats inoculated with 50 μg gp-MBP on day 0 compared to clinical scores (bottom set). In both males and females, EAE clinical scores of rats immunized with MBP were significantly greater than those of APL-treated or CFA-immunized (control) animals during period of established disease. (A) In males, APL conferred significant increase in mechanical threshold compared to MBP-treated rats on day 11, 14, 16. (B) In females, MBP animals generally exhibited lower pain thresholds, while APL animals maintained thresholds similar to control. (n = 6 per group; *p < 0.05, ****p < 0.0001, MBP compared to control; ∘p < 0.05, ∘∘p < 0.01, APL compared to MBP; two-way ANOVA with Bonferroni’s post-tests for upper panel, Mann–Whitney test for lower panel). Gray region indicates periods of established disease. Dotted line represents mean baseline values. Data expressed as mean ± SEM.