Table 1.
Relationship between THBS1 differential gene expression, promoter methylation, mRNA expression, and TP53 mutations in ovarian cancer cell lines.
| THBS1 promoter methylation percent | Wilcoxon rank sum | THBS1 gene expression | Wilcoxon rank sum | ||
|---|---|---|---|---|---|
| n | Median (IQR) | p | Median (IQR) | p | |
| TP53 MUTATION | |||||
| Null | 3 | 8.7 (8.0–9.4) | 1.0* | 9.9 (9.9–10.5) | 0.005* |
| Wild type | 5 | 8.9 (8.6–9.2) | 10.1 (9.5–12.5) | ||
| Missense | 9 | 8.1 (7.8–47.1) | 7.5 (5.1–7.9) | ||
| Frame Deletion | 1 | 8.0 | 9.6 | ||
| TP53 PROTEIN OVEREXPRESSION | |||||
| No: 0 or 1+ | 7 | 8.6 (7.8–10.0) | 1.0 | 10.2 (8.9–12.2) | 0.008 |
| Yes: 2+ | 9 | 8.1 (7.8–47.1) | 7.9 (5.1–9.4) | ||
*There were too few observations in each group for comparison testing. Therefore THBS1 gene expression was compared in the samples with missense mutations to those with null mutations and intact wild-type TP53 gene combined.