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Interaction between sex and insulin resistance on hypothalamic volume. “Lean Control” (n = 34 females and 18 males), represented by closed circles, are lean adolescents without evidence of tissue insulin resistance. “IR/T2DM” (n = 23 females and 16 males), represented by open circles, are obese adolescents with either marked insulin-resistance but not diabetes and/or obese adolescents with type 2 diabetes mellitus.
