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. 2013 Oct 29;7:175. doi: 10.3389/fncir.2013.00175

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Copyright © 2013 Sivaramakrishnan, Sanchez and Grimsley.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Local circuits in vivo show temporal variations. (A,B) Examples of HiDi effects on two neurons. (A) At 30 dB SPL, which was 15 dB above threshold for this neuron, HiDi did not affect spiking. At 70 dB SPL, HiDi reduced spiking, but mainly at later times during the tone. Rate-level functions plotted in different time windows during the tone for this cell (right column) show little effect of HiDi immediately following tone onset, but a larger effect ~20 ms after tone onset and 20 dB above threshold. (B) In a second neuron, HiDi does not affect firing at 15 dB SPL, but reduces firing at 25 dB SPL which corresponds to the peak of the control RIF (right column). HiDi has almost no effect at intensities corresponding to the downward limb of the RIF. HiDi does not affect responses soon after onset (top graph, right column), but its effect in successive time windows is similar.