Figure 3. Ranolazine augments insulin-stimulated whole body glucose disposal.

Each rat received a primed (10 mg kg⁻¹) continuous (9.6 mg kg⁻¹ h⁻¹) i.v. infusion of ranolazine or the same volume of saline for 150 min. A euglycaemic insulin clamp (3 mU kg⁻¹ min⁻¹) was started 30 min after each rat began receiving ranolazine or saline (0 min) and continued for 120 min. A, time course of glucose infusion rate (GIR) during insulin clamp; B, area under the curve of GIR during insulin clamp; C, blood glucose concentrations; D, MAP. n= 5 each. *P < 0.05 vs. control.