Figure 7. Effect of ranolazine on skeletal muscle insulin uptake.

Each rat received a primed (10 mg kg⁻¹) continuous (9.6 mg kg⁻¹ h⁻¹) infusion of ranolazine or the same amount of saline for 25 min, and a bolus i.v. injection of ¹²⁵I-insulin (1.5 μCi) at 25 min. Blood and skeletal muscle were collected 5 min afterwards. Total and intact ¹²⁵I-insulin was determined after TCA (30%) precipitation in both blood and muscle. A, muscle clearance of plasma insulin; B, muscle insulin uptake; C, fraction of intact ¹²⁵I-insulin in blood and muscle. n= 5 each. *P < 0.05 vs. control.