Figure 1.

Summary of PROM1 promoter architecture and cross-platform activity. Upper panel: CD133 promoter structure with known promoter regions P1–P5 (black rectangles), novel proximal promoter P6 (white rectangle), known exons A–E (gray rectangles), and CpG islands (~). Lower panel: Promoter activity (colored rectangles, number of studies expressing that category) in normal tissues, cancer, and developmental systems/stem cells as captured by different platforms. Orange: known promoter activities reported in the literature based on single gene studies. Blue: CAGE and RNA seq studies. Green: Affymetrix exon array exome expression. Promoters P1–P3 are widely expressed in the literature and using CAGE and RNA-seq assay. P6 is not yet reported in the literature.