Table 1.

PROM1 alternative promoters and regulation.

Promoter	Genomic location	Distance from start codonc	Tissue	Transcription factors	References
P1a, b	16085637 – 16087537	−10008	Fetal liver, liver, kidney, pancreas, placenta, lung, spleen, colon, small intestine, and prostate Glioblastoma, lung cancer	OCT4, SOX2 (during hypoxia), Sp1/Myc	Shmelkov et al., 2004; Iida et al., 2011; Gopisetty et al., 2012
P2a, b	16085338 – 16085704	−8175	Brain, ovary, kidney, liver, pancreas, placenta, lung, spleen and colon Glioblastoma	Sp1/Myc	Shmelkov et al., 2004; Tabu et al., 2008; Gopisetty et al., 2012
P3a	16084913 – 16085337	−7808	Skeletal muscle	Sp1/Myc	Shmelkov et al., 2004; Gopisetty et al., 2012
P4	16082163 – 16083762	−6233	Testis	Not studied	Shmelkov et al., 2004; Tabu et al., 2008
P5	16122394 – 16123893	−46364	Testis	ETS	Shmelkov et al., 2004; Tabu et al., 2008, 2010
P6	16077254 – 16077627	−98	Cancer, stem cells, and retina	HMG	–

^aContains CpG island.

^bHypomethylated in glioblastomas.

^cStart codon at location 16077529 in Exon 2 (16077741 – 16077309).