Table 2.
Nitric oxide release characteristics of 5 wt% NO-releasing silica particle-doped 12% (w/v) electrospun fiber mats.
| NO donor type | NO-releasing silica particle | Type of polyurethaneb | [NO]maxc (pmol mg−1 s−1) | tmaxd (min) | Total NO releasede (nmol mg−1) | tdf (h) |
|---|---|---|---|---|---|---|
| N-diazeniumdiolate | AHAP3/TEOSa (50 nm) | Tecophilic | 28.0 ± 9.2 | 8.4 ± 5.5 | 62.5 ± 36.1 | 7.2 ± 3.6 |
| Tecoflex | 13.1 ± 10.1 | 24.0 ± 16.2 | 69.4 ± 18.3 | 13.3 ± 4.1 | ||
| Tecoplast | 3.2 ± 2.6 | 28.5 ± 1.1 | 60.9 ± 15.2 | 29.9 ± 12.8 | ||
| AHAP3/TEOSa (100 nm) | Tecophilic | 17.6 ± 3.8 | 1.2 ± 0.1 | 57.0 ± 6.4 | 14.5 ± 0.2 | |
| Tecoflex | 22.3 ± 2.9 | 2.6± 1.9 | 37.3 ± 10.9 | 14.9 ± 0.8 | ||
| Tecoplast | 19.7 ± 1.7 | 1.9 ± 1.5 | 42.2 ± 19.8 | 14.1 ± 0.2 | ||
| AEAP3/TMOS | Tecophilic | 2.2 ± 1.0 | 1.7 ± 0.5 | 15.0 ± 5.0 | 15.3 ± 1.0 | |
| Tecoflex | 1.5 ± 0.9 | 0.8 ± 0.5 | 10.8 ± 1.0 | 19.6 ± 2.7 | ||
| Tecoplast | 1.3 ± 0.3 | 3.1 ± 2.7 | 7.5 ± 2.0 | 14.3 ± 1.6 | ||
| S-nitrosothiol | MPTMS/TEOS | Tecophilic | 15.2 ± 6.1 | 6.9 ± 0.4 | 124.7 ± 6.8 | 366.8 ± 78.2 |
| Tecoflex | 10.1 ± 0.8 | 0.9 ± 0.4 | 123.2 ± 16.1 | 296.6 ± 6.5 | ||
| Tecoplast | 11.7 ± 9.8 | 1.8 ± 1.0 | 86.8 ± 9.0 | 299.9 ± 2.8 |
a
AHAP3/TEOS particles have two distinct sizes but similar NO release properties;
b
Hydrophobicity increases from top to bottom of one particle system;
c
Maximum instantaneous concentration of NO released as measured with NOA;
d
Time required to reach [NO]max;
e
Total number of moles of NO released per mg of particle-doped electrospun fiber mat as measured by the Griess assay;
f
Duration of NO release (time to release 99% of total NO).