Table 2.

Comparing the hazard ratios of death associated with time-dependent and time-averaged TSAT categories in 2247 MHD patients with PKD, by case-mix + MICS adjusted and fully adjusted models

	Case-mix + MICS adjusted			Fully adjusted
Category	HR	95% CI	P-value	HR	95% CI	P-value
Time-dependent TSAT (%)
<20%	1.27	0.99–1.63	0.06	1.12	1.08–1.14	<0.0001
20 to <30%a	1	1		1	1
30 to <40%	0.74	0.58–0.94	0.01	0.93	0.91–0.96	<0.0001
40 to <50%	0.99	0.73–1.35	0.96	0.93	0.89–0.96	0.0001
≥50%	1.28	0.89–1.83	0.19	1.05	1.00–1.09	0.03
Time-averaged TSAT (%)
<20%	2.19	1.51–3.19	<0.0001	2.44	1.7–3.49	<0.0001
20 to <30%a	1	1		1	1
30 to <40%	0.74	0.57–0.95	0.02	0.77	0.59–1.0	0.0534
40 to <50%	1.34	0.9–2.01	0.15	1.38	0.91–2.11	0.1291
≥50%	1.59	0.80–3.16	0.19	1.84	0.88–3.85	0.1048

MHD, maintenance hemodialysis; PKD, polycystic kidney disease; TSAT, transferrin saturation; CI, confidence interval.

^aReference group.