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. Author manuscript; available in PMC: 2014 Sep 15.
Published in final edited form as: Toxicology. 2013 Jul 10;311(3):10.1016/j.tox.2013.07.002. doi: 10.1016/j.tox.2013.07.002

Fig. 3.

Fig. 3

PPARβ/δ-dependent modulation of a urinary ethanol metabolite and ethanol metabolizing enzymes after four months of feeding. (A) Relative urinary abundance of MS/MS validated ethyl-β-d-glucuronide in control and ethanol-fed Pparβ/δ+/+ and Pparβ/δ−/− mice. (B) Average expression of hepatic mRNA encoding Cyp2e1 in control and ethanol-fed Pparβ/δ+/+ and Pparβ/δ−/− mice. Average urinary concentration of ethyl-β-d-glucuronide and normalized Cyp2e1 mRNA values represent the mean ± S.E.M.. (C) Western blot analysis of CYP2E1 in the liver of control and ethanol-fed Pparβ/δ+/+ and Pparβ/δ−/− mice. (D) Average expression of hepatic mRNA encoding different Ugt mRNAs in control and ethanol-fed Pparβ/δ+/+ and Pparβ/δ−/− mice. Normalized values represent the mean ± S.E.M.. Values with different superscripts are statistically different at P ≤ 0.05.