. Author manuscript; available in PMC: 2014 Sep 1.

Published in final edited form as: Vet Clin North Am Small Anim Pract. 2013 Sep;43(5):10.1016/j.cvsm.2013.05.002. doi: 10.1016/j.cvsm.2013.05.002

Table 1.

Pharmacokinetic parameters determined for drugs that have longer (or shorter) elimination half-life values in cats versus dogs and humans. Results are the averages of published studies as referenced. Data from Obach et al, 2008 ¹ represent a compilation of all available human data up to 2008. Intravenous administration data were used if available to exclude bioavailability differences.

Drug	Species	Half-life (h)	CL (mL/min/kg)	Vd (L/kg)
Acetylsalicylic acid^*	Cat	22	0.088	0.17
	Dog	4.5	0.68	0.29
	Human	2.3	0.66	0.19
Acetaminophen	Cat^**	5.0	2.9	1.3
	Dog^**	1.1	13	1.3
	Human^**	2.6	5	1.0
Propofol	Cat	8.8	17	6.8
	Dog	2.4	51	5.1
	Human	1.9	30	4.7
Carprofen	Cat	18	0.10	0.15
	Dog	12	0.28	0.17
	Human^**	12	0.48	0.48
Piroxicam	Cat	11	0.52	0.48
	Dog	40	0.044	0.29
	Human^**	47	0.050	0.16

Data from Refs ^1-15.

Data for disposition of the active metabolite, salicylic acid.

^**

Oral dosing data provided since IV or other parental administration data not available. CL is therefore CL/F and Vd is Vd/F. However for these drugs bioavailability is considered to be high.