Table 4.
Multivariable association between DHEAS* and ischemic stroke by key risk factors
| Stratification Factor | Cases/Controls | RR (95% CI) | Pinteraction |
|---|---|---|---|
| Age | |||
| <65 | 307/309 | 1.89 (1.26-2.85) | 0.06 |
| ≥65 | 154/152 | 1.09 (0.67-1.79) | |
| BMI | |||
| <25 | 226/254 | 1.39 (0.90-2.15) | 0.49 |
| ≥25 | 235/207 | 1.57 (0.98-2.52) | |
| Smoking | 0.11 | ||
| Never | 193/192 | 2.17 (1.32-3.56) | |
| Former | 186/193 | 1.30 (0.80-2.13) | |
| Current† | 82/76 | 0.85 (0.35-2.04) | |
| Diabetes ‡ | 0.03 | ||
| No | 403/433 | 1.36 (0.99-1.87) | |
| Yes | 58/28 | 2.00 (0.51-7.86) | |
| Postmenopausal Hormone Therapy Use § | 0.56 | ||
| No | 215/217 | 1.45 (1.07-1.98) | |
| Yes | 195/194 | 1.44 (1.05-1.96) | |
| Ovarian Status | 0.54 | ||
| Intact | 334/328 | 1.36 (0.93-1.98) | |
| >1 ovary removed | 127/133 | 1.83 (1.01-3.32) | |
*
Lowest quartile vs. quartiles 2-4
Models adjusted for covariates in Model 3 of Table 3, except stratification factor
†
Current smokers not adjusted for
‡
Adjusted for matching factors only due to sample size constraints
§
Reference is postmenopausal non-hormone therapy use; premenopausal and dubious excluded