Table I. Antidepressants demonstrating efficacy in borderline personality disorder. MAOI, monoamine oxidase inhibitor; SSRIs, selective serotonin reuptake inhibitors.

Medication	Dosing	Effects
MAOIs
Phenelzine	15-90 mg/d	Improvements primarily in depression, impulsive aggression. Some patients experience uncomfortable activation.
Tranylcypromine	Mean dose 40 mg/d	Improvements primarily in affective symptoms, interpersonal sensitivity, but limited data.
SSRIs
Fluoxetine	20-80 mg/d	Mild improvements in affective symptoms, anger, impulsive aggression. Effects may be pronounced in males, patients with high levels of impulsive aggression.
Fluvoxamine	150-250 mg/d	Mild improvement in affective instability, not impulsivity.
Paroxetine	20-40 mg/d	Possible decrease in suicidality without significant effect on depression, though limited data.