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. 2013 Sep;15(3):359–384. doi: 10.31887/DCNS.2013.15.3/edennis

Table I. Studies investigating typical development that are reviewed in this paper. Bold indicates study that examined age* diagnosis effect. *, no gender information; AD, autism; ADHD, attention deficit/hyperactivity disorder; PBD, pediatric bipolar disorder; FX, fragile X; DD, developmental delay; 22q, 22q11.2 deletion syndrome; WS, Williams syndrome; DS, Down syndrome; TS, Turner syndrome; TD, typically developing; (# F), number of female participants; yo, years old; mo, months old; MRI, magnetic resonance imaging; GMD, gray matter density; DTI, diffusion tensor imaging; ROI, region of interest; HARDI, high angular resolution diffusion imaging; ICA, independent components analysis; ‡ indicates study for which we have included a figure.

Study N Ages Modality
Structural MRI
Giedd et al, 1999 145 (56 F) 4-22 overall Brain wolume
Gogtay et al, 2004‡ 13 (7 F) 4-21 yo overall Brain volume
Sowell et al, 2002 35 (15 F) 7-16 yo Brain volume
Sowell et al, 2003 1796(86 F) 7-87 yo Brain volume (GMD)
Sowell et al, 2004 45 (22 F) 5-10 yo baseline Cortical thickness
Hua et al, 2009‡ 13 (6 F) 6-15 yo baseline Brain volume
Tamnes et al, 2010 168 (87 F) 8-30 yo Brain volume, cortical thickness, and DTI
Diffusion-weighted imaging
Klingberg et al, 1999 7 children, 5 adults, all male 8-12 and 20-31 yo DTI - ROI
Schmithorst et al, 2002 33 (17 F) 5-18 yo Voxel-wise DTI
Barnea-Goralyetal, 2005 34 (16 F) 6-19 yo Voxel-wise DTI
Bonekamp et al, 2007 40 (18 F) 5-19 yo DTI - ROI
Eluvathingal et al, 2007 31 (16 F) 6-17 yo DTI - ROI (tract-based)
Qiu et al, 2008 1: 24 (11 F), 2: 27 (11 F), 3: 24 (13 F) 1:6-8, 2:9-12, 3:18-26 yo Voxel-wise DTI
Lebel et al, 2008‡ 202 (98 F) 5-30 yo DTI - ROI (tract based)
Kochunov et al, 2010 831 (485 F) 11-90 yo DTI - ROI (tract-based)
Hagmann et al, 2010 30 (17 F) 18 mo-18 yo DTI - graph theory
Dennis et al, 2013‡ 439 (267 F) 12,16, 20-30 yo HARDI - graph theory
Dennis et al, 2013b 438(266 F) 12,18, 20-30 yo HARDI - graph theory
Functional connectivity
Fair et al, 2007, 2008‡ 210 (*) 7-9,10-15,19-31 yo Seed-based func. conn.
Kelly et al, 2009 1:14 (4 F), 2: 12 (5 F), 3: 14 (5 F) 1:8-13, 2:14-17, 3:20-24 yo Seed-based func. conn.
Dosenbach et al, 2010 238 (115 F) 7-30 yo Seed-based func. conn.
Supekar et al, 2010 1: 23 (13 F), 2: 22 (11 F) 1: 7-9, 2: 19-22 yo DTI, ICA func. conn.
Thomason et al, 2011 65 (32 F) 9-15 yo baseline Seed/ICA func. conn.
JoIIes et al, 2011 1:19(10 F), 2: 29 (16 F) 1: 11-13, 2: 19-25 yo ICA func. conn.