Table 2.

Daptomycin cure rate of MRSA infections by daptomycin MIC^a

Daptomycin MIC, μg/mlb	Cure, nc	Total, nd	Cure rate, % (95% CI)e	References
≤1	376	434	86.6 (83.4–89.8)	11, 12, 73, 202–217
2	15	31	48.4 (30.8–66.0)	12, 98, 202, 216–222
4	3	14	21.4 (0.0–42.9)	12, 216, 217,223, 224
≥8	0	2	0	76, 77

^aMRSA, methicillin-resistant Staphylococcus aureus.

^bMIC by broth microdilution, Etest, or automated method. The isolate with the highest MIC was included. Etest results were rounded up to the nearest dilutional integer for comparison.

^cMicrobiological or clinical cure. Where both were presented in a relevant study, the lower cure rate was chosen for a more conservative estimate.

^dData pooled from multiple studies and case reports, with additional data clarification by the study authors where possible. See Table S1 in the supplemental material for further details.

^e95% CI, 95% confidence interval.