Table 3.
Properties of spontaneous pacidamycin-resistant P. aeruginosa mutants
| Strain | Description | MIC (μg/ml) |
||||
|---|---|---|---|---|---|---|
| Pacidamycin | Levofloxacin | Carbenicillin | Erythromycin | Imipenem | ||
| PAO1 | Wild type | 4–16 | 0.25 | 32 | 128 | 1 |
| Type 1 | High-level resistance | |||||
| PAM1135 | pac-1 | >512 | 0.25 | 32 | 128 | 1 |
| Type 2 | Low-level resistance | |||||
| PAM1043 | MexAB-OprM up | 64 | 1 | 256 | 256 | 1 |
| PAM1044 | MexCD-OprJ up | 64 | 2 | 16 | >512 | 0.125 |
| Controls | ||||||
| PAM1032 | nalB (MexAB-OprM up) | 64 | 1 | 256 | 256 | 1 |
| PAM1033 | nfxB (MexCD-OprJ up) | 64 | 2 | 16 | >512 | 0.25 |
| PAM1034 | nfxC (MexEF-OprN up) | 16 | 4 | 16 | 128 | 4 |