Fig 2.

Killing activity of doripenem (Dori) against KPC-K. pneumoniae strains, stratified by doripenem MICs (A) and the presence of ompK36 mutations (B). The data represent the median log₁₀ kills by doripenem. (A) P values indicate the differences in killing by doripenem against 4 strains with doripenem MICs of ≤8 μg/ml and 19 strains with MICs of >8 μg/ml. (B) P values indicate the differences in killing by doripenem against 8 ins aa134-135 GD mutants, 7 IS5 mutants, and 8 ompK36 other mutant/wild-type strains (ANOVA).