Fig 4.

In vivo effects of psilostachyin A (A and B) and cynaropicrin (C to F) in acute mouse models of infection using different T. cruzi strains: Y (A to D) and Colombiana (E and F). Parasitemia (A, C, and E) and cumulative mortality (B, D, and F) data are shown. (A and B) The effects of psilostachyin A (Psilo) (i.p.) and Bz (p.o.) were followed using doses of up to 50 mg/kg/day, administered at 5 and 8 dpi. (C and D) The effects of cynaropicrin (cyna) and Bz were followed using doses of up to 50 mg/kg/day for cynaropicrin (i.p.) and 100 mg/kg/day for Bz (p.o.), administered at 5 and 8 dpi. (E and F) The effects of cynaropicrin and Bz were followed using doses of 25 mg/kg/day for cynaropicrin (i.p., b.i.d.) and 100 mg/kg/day for Bz (p.o.), administered for 2 consecutive days starting at the onset of parasitemia (11 dpi).