Table 1.
Study design
| Group | No. of animalsa | AVA dose (dilution of human dose), days 1 and 8 | AIGIV dose (mg/kg of anti-PA IgG), day 1 | Gamunex dose (mg/kg), day 1 |
|---|---|---|---|---|
| 1 | 8 | 1:16 | ||
| 2 | 8c | 14.2 | ||
| 3 | 8c | 21.3 | ||
| 4 | 8c | 1:16 | 14.2 | |
| 5 | 8 | 1:16 | 21.3 | |
| 6 | 8 | 1:16 | 546b |
a
Equal numbers of male and female NZW rabbits, weighing between 3.2 and 4.7 kg at the start of the study, were used.
b
Equivalent dose of total IgG as AIGIV at a dose of 21.3 mg/kg.
c
Three rabbits, one in each of groups 2, 3, and 4, did not receive a full dose of AIGIV and were therefore excluded from the PK analysis.