Table 3.

Posaconazole monotherapy doses and total- and free-drug AUC/MIC ratios needed to achieve net stasis and 1-log kill endpoints (when achieved) for each isolate

Isolate	Stasis				1-log kill
	Dose (mg/kg/24 h)	MIC (mg/liter)	24-h total-drug AUC/MIC	24-h free-drug AUC/MIC	Dose (mg/kg/24 h)	24-h total-drug AUC/MIC	24-h free-drug AUC/MIC
DPL	1.87	0.25	85.1	0.85	3.12	142	1.42
EMFR S678P	1.09	0.25	49.7	0.50	2.28	104	1.04
F16216	>40	2	Xa	X	>40	X	X
F11628	>40	8	X	X	>40	X	X

^aX, not attainable.