Table 1.
In vitro susceptibilities of select C. albicans, C. glabrata, and C. tropicalis isolates to isavuconazole (BAL4815), fluconazole, voriconazole, and posaconazole
| Species | Isolate | MIC (mg/liter)a of: |
||||
|---|---|---|---|---|---|---|
| Isavuconazole |
Fluconazole | Voriconazole | Posaconazole | |||
| CLSI | EUCAST | |||||
| C. albicans | K1 | 0.004 | 0.004 | 0.25 | 0.007 | 0.03 |
| 580 | 0.008 | 0.015 | 4 | 0.03 | 0.06 | |
| 98-210 | 0.03 | 0.12 | 16 | 0.03 | 0.125 | |
| 2183 | 0.008 | 0.008 | >128 | 0.06 | 0.06 | |
| 98-17 | 0.03 | 0.06 | 16 | 0.125 | 0.125 | |
| C. tropicalis | 98-234 | 0.016 | 0.008 | 32 | 0.25 | 0.125 |
| C. glabrata | 35315 | 0.125 | 0.06 | 0.25 | <0.03 | 0.06 |
| 14378 | 0.25 | 0.25 | 2 | |||
a
The MICs of fluconazole, voriconazole, and posaconazole were determined by the CLSI method. The isavuconazole MIC was determined both by the CLSI method and by the EUCAST method.