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Cross-resistance profiling of GSK5852 or HCV-796 on HCV mutants. Genotype 1b replicons containing the indicated amino acid changes in NS3, NS4B, NS5A, and NS5B were constructed by site-directed mutagenesis. The mean EC50s for GSK5852 or HCV-796 were determined by transient-transfection assays (n ≥ 4) and compared to the Con1 EC50 to calculate fold changes.
