Inter- and intragenotypic activity of GSK5852. The mean EC50s for genotype 1a, 1b, 4a, and 5a patient sequence replicons and genotype 2a, 2b, and 3a consensus sequence replicons are represented by open circles (○), and the Con1 replicon is represented by the filled circles (●). EC50s were determined by transient transfection for genotype 1a and 1b and with stable cell lines for the non-genotype 1 chimeric replicons (n ≥ 4).