Table 1.
Comparison of GSK5852 and HCV-796 in stable replicon and HCVcc assays
| Assay system | GSK5852 |
HCV-796 |
||||
|---|---|---|---|---|---|---|
| EC50 (nM) | 95% confidence interval (nM) | n | EC50 (nM) | 95% confidence interval (nM) | n | |
| Genotype 1a replicon (H77) | 3.0 | 2.8–3.3 | 82 | 26.1 | 24.2–28.3 | 139 |
| Genotype 1b replicon (Con1) | 1.6 | 1.5–1.8 | 125 | 16.9 | 16.0–17.7 | 581 |
| Genotype 1b replicon (C316N) | 1.9 | 1.6–2.2 | 26 | 257 | 242–274 | 241 |
| Genotype 2a replicon (JFH1) | 7.6 | 6.4–8.9 | 16 | 92.6 | 80.7–106 | 10 |
| HCVcc virus (Jc1p7Fluc2a) | 47 | 34–61a | 2 | 95 | 93–98a | 2 |
a
Range for values with n of <4.