Table 3.

Amino acid substitutions encoded by C. gattii or C. neoformans ERG11 cDNAs^a

Strainb	Genotype	Fluconazole MIC (μg/ml)	Q7R	V8A	V15L	Y18F	I19F	H21P	T24A	L30V	I32V	V33A	I37V	F42L	I43V	G45C	H50Q	R57K	R57T	R58K	D59N	D80N	I99L	M101T	I105V	S191P	I196A	S203A	E223V	N249D	R256K	F268L	G293S	V307I	V340I	E349Q	K362R	A404S	A457V	T460S	N533T
R265	VGIIa	16
WM 276	VGI	4																+		+	+	+	+	+			+		+			+
H99		8				+		+	+	+	+			+	+	+	+			+					+	+	+				+		+	+		+		+		+
JEC21		4				+	+	+	+		+	+	+	+			+	+	+			+				+	+	+			+		+	+		+	+	+	+
C1	VGIIb	64
C6	VGIIa	64
C8	VGIIa	64
C71	VGIIc	64																												+
C2	VGIIa	32
C14	VGIIc	32																												+
C59	VGIIa	32
C61	VGIIa	32
C4	VGIIa	16
C5	VGIIa	16
C7	VGIIa	16
C9	VGIIa	16
C11	VGIIa	16
C15	VGIIc	16
C16	VGI	16			+			+									+		+	+							+								+						+
C57	VGIIa	16
C60	VGIIa	16
C62	VGIIa	16
C63	VGIIa	16
C66	VGIIa	16
C67	VGIIa	16
C3	VGIII	8	+	+				+									+			+							+
C10	VGIIa	8
C17	VGI	8			+			+									+		+	+							+								+						+
C64	VGIIa	8

^a+, substitution encoded. Amino acids that differ from C. gattii R265 Erg11p are listed.

^bAll except C. neoformans H99 and JEC21 are C. gattii.