Table 4.

Effects of heterologous ERG11 expression on susceptibility of S. cerevisiae DSY3961 to antifungals

Source of ERG11	Geometric mean of the MIC (μg/ml)a
	Fluconazole	Voriconazole	Itraconazole	Posaconazole	Amphotericin B
Empty plasmidb	1	0.032	0.032	0.128	2
S. cerevisiae DSY3961	8	0.25	0.5	0.5	2
C. albicans SC5314	8	0.25	0.25	0.5	2
C. albicans 17 (R467K)	32	0.125	0.25	0.5	2
C. neoformans H99	0.250	0.002	0.031	0.063	2
C. neoformans JEC21	0.125	0.001	0.015	0.063	2
C. gattii R265	0.250	0.002	0.036	0.055	2
C. gattii WM276	0.149	0.001	0.015	0.031	2
C. gattii C71 (N249D)	0.250	0.002	0.015	0.041	2
C. gattii C3	0.177	0.002	0.015	0.026	2
C. gattii C16	0.210	0.001	0.018	0.031	2
C. gattii C17	0.149	0.002	0.015	0.024	2

^aMICs were measured in YNB − His, Leu, Ura containing 3% galactose, 2% raffinose, and 2 μg doxycycline/ml. n = 3 or more for all azoles; n = 2 for amphotericin B.

^bEmpty-plasmid controls were tested without doxycycline.