Table 3.

MICs and RE of genes harboring efflux pumps^c

Straina	MICd (mg/liter)										REb
	TIG	GEN	AMK	DOX	MIN	TET	NET	RIF	TOB	DOR	adeBb	adeJ	adeG	craA	abeM	amvA
44	≤0.25	2	32	16	1	>64	>64	2	32	64	26.60	1.69	0.68	1.47	0.39	0.002
45	≤0.25	2	32	16	1	>64	>64	1	64	>64	15.00	1.21	0.67	0.71	0.43	0.001
47	≤0.25	4	16	16	1	>64	>64	1	64	64	19.50	1.29	0.80	0.53	0.45	0.002
61	≤0.25	4	16	16	4	>64	>64	2	64	64	23.25	1.24	0.34	0.99	0.15	0.005
62	≤0.25	2	32	16	1	>64	>64	1	64	>64	20.19	1.67	0.49	0.49	0.17	0.002
95	≤0.25	4	32	16	1	>64	>64	<0.5	32	>64	33.95	1.33	1.06	0.32	0.22	0.002
40	0.5	4	32	16	1	>64	>64	1	64	64	12.88	0.25	0.59	0.91	0.36	0.001
46	0.5	2	32	16	1	>64	>64	1	64	>64	10.82	1.70	0.84	1.18	0.38	0.002
48	0.5	8	32	16	1	>64	>64	1	64	64	10.28	1.13	1.04	0.81	0.33	0.002
50	0.5	2	64	16	<0.5	>64	>64	2	64	64	11.91	1.25	0.44	0.70	0.41	0.002
60	0.5	4	64	16	1	>64	>64	1	64	64	29.20	1.52	0.36	1.18	0.41	0.003
72	0.5	2	32	16	<0.5	>64	>64	1	32	>64	24.94	1.19	0.87	0.73	0.23	0.004
73	0.5	2	32	16	<0.5	>64	>64	2	64	>64	7.53	1.21	0.60	0.72	0.17	0.004
74	0.5	>64	<2	32	4	>64	64	4	4	>64	22.19	1.08	0.51	0.68	0.17	0.003
75	0.5	>64	4	16	4	>64	64	4	4	>64	13.95	0.84	0.49	0.52	0.17	0.002
96	0.5	4	32	16	1	>64	>64	1	64	64	8.55	1.46	0.97	0.31	0.22	0.002
63	1	4	16	16	1	>64	>64	1	32	64	43.11	1.87	0.41	0.59	0.23	0.005
67	1	64	32	16	<0.5	>64	>64	1	64	>64	44.95	0.81	0.63	0.45	0.19	0.002

^aStrains are ranked according to the MIC of tigecycline.

^bIncreased gene RE values of ≥2 are indicated in bold.

^cThe reference strain used was A. baumannii ATCC 17978. RNA (50 μg/ml) was from strains of the PFGE-ROC-1_OXA24 clone.

^dTIG, tigecycline; GEN, gentamicin; AMK, amikacin; DOX, doxycycline; MIN, minocycline; TET, tetracycline; NET, netilmicin; RIF, rifampin; TOB, tobramycin; DOR, doripenem.