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. 2013 Nov;57(11):5247–5257. doi: 10.1128/AAC.00730-13

Table 3.

MICs and RE of genes harboring efflux pumpsc

Straina MICd (mg/liter)
REb
TIG GEN AMK DOX MIN TET NET RIF TOB DOR adeBb adeJ adeG craA abeM amvA
44 ≤0.25 2 32 16 1 >64 >64 2 32 64 26.60 1.69 0.68 1.47 0.39 0.002
45 ≤0.25 2 32 16 1 >64 >64 1 64 >64 15.00 1.21 0.67 0.71 0.43 0.001
47 ≤0.25 4 16 16 1 >64 >64 1 64 64 19.50 1.29 0.80 0.53 0.45 0.002
61 ≤0.25 4 16 16 4 >64 >64 2 64 64 23.25 1.24 0.34 0.99 0.15 0.005
62 ≤0.25 2 32 16 1 >64 >64 1 64 >64 20.19 1.67 0.49 0.49 0.17 0.002
95 ≤0.25 4 32 16 1 >64 >64 <0.5 32 >64 33.95 1.33 1.06 0.32 0.22 0.002
40 0.5 4 32 16 1 >64 >64 1 64 64 12.88 0.25 0.59 0.91 0.36 0.001
46 0.5 2 32 16 1 >64 >64 1 64 >64 10.82 1.70 0.84 1.18 0.38 0.002
48 0.5 8 32 16 1 >64 >64 1 64 64 10.28 1.13 1.04 0.81 0.33 0.002
50 0.5 2 64 16 <0.5 >64 >64 2 64 64 11.91 1.25 0.44 0.70 0.41 0.002
60 0.5 4 64 16 1 >64 >64 1 64 64 29.20 1.52 0.36 1.18 0.41 0.003
72 0.5 2 32 16 <0.5 >64 >64 1 32 >64 24.94 1.19 0.87 0.73 0.23 0.004
73 0.5 2 32 16 <0.5 >64 >64 2 64 >64 7.53 1.21 0.60 0.72 0.17 0.004
74 0.5 >64 <2 32 4 >64 64 4 4 >64 22.19 1.08 0.51 0.68 0.17 0.003
75 0.5 >64 4 16 4 >64 64 4 4 >64 13.95 0.84 0.49 0.52 0.17 0.002
96 0.5 4 32 16 1 >64 >64 1 64 64 8.55 1.46 0.97 0.31 0.22 0.002
63 1 4 16 16 1 >64 >64 1 32 64 43.11 1.87 0.41 0.59 0.23 0.005
67 1 64 32 16 <0.5 >64 >64 1 64 >64 44.95 0.81 0.63 0.45 0.19 0.002
a

Strains are ranked according to the MIC of tigecycline.

b

Increased gene RE values of ≥2 are indicated in bold.

c

The reference strain used was A. baumannii ATCC 17978. RNA (50 μg/ml) was from strains of the PFGE-ROC-1OXA24 clone.

d

TIG, tigecycline; GEN, gentamicin; AMK, amikacin; DOX, doxycycline; MIN, minocycline; TET, tetracycline; NET, netilmicin; RIF, rifampin; TOB, tobramycin; DOR, doripenem.