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. 2013 Nov;57(11):5247–5257. doi: 10.1128/AAC.00730-13

Table 5.

Interplay of mechanisms of resistance to several antibiotics of the strains of clones PFGE-ROC-1 and PFGE-HUI-1 under study

Antibiotic(s) Mechanism of resistance
PFGE-ROC-1OXA-58 PFGE-ROC-1OXA-24 PFGE-HUI-1
Tigecycline Overexpression of AdeIJK Overexpression of AdeABC New RND efflux system/TetA(39) efflux pumpc
Gentamicin Overexpression of AdeABC/acetylases (aacC1, aphA1, aadB) Overexpression of AdeABC/acetylases (aacC1, aphA1, aadB) Acetylases (aacC1, aphA1, aadB)
Minocycline Overexpression of AdeIJK/TetB efflux pumps Overexpression of AdeABCb
Netilmicin, tobramycin, and amikacin Acetylases (aacC1, aphA1, aadB) Acetylases (aacC1, aphA1, aadB) Acetylases (aacC1, aphA1, aadB)
Imipenem, meropenem, and doripenem OXA-58 β-lactamase OXA-24 β-lactamase
Ciprofloxacin Mutations in gyrA and parC Mutations in gyrA and parC Mutations in gyrA and parC
Doxycycline Overexpression of AdeIJKa/TetB efflux pumps TetB efflux pump TetA(39) efflux pumpc
Tetracyclines TetB efflux pump TetB efflux pump TetA(39) efflux pumpc
a

Nonsignificantly increased expression relative to strains with doxycycline resistance.

b

Only three isolates, 61, 74, and 75.

c

Except for strains 421, 422, 423, 424, and 426.