Table 2.
Concentrations of drugs in patient plasma, DBS, and VDBS samples
| Drug and sample | Concn (mg/liter) of drug in: |
||
|---|---|---|---|
| Plasma | DBS | VDBS | |
| Voriconazole | |||
| Sample 1 | 0.1 | 0.1 | 0.1 |
| Sample 2 | 0.4 | 0.5 | 0.5 |
| Sample 3 | 0.7 | 0.8 | 0.8 |
| Sample 4 | 1.0 | 1.3 | 1.2 |
| Sample 5 | 1.6 | 1.4 | 1.9 |
| Sample 6 | 1.6 | 1.5 | 2.0 |
| Sample 7 | 1.9 | 2.1 | 2.1 |
| Sample 8 | 2.5 | 2.9 | 3.0 |
| Sample 9 | 3.7 | 3.1 | |
| Sample 10 | 4.2 | 4.5 | 4.6 |
| Sample 11 | 9.9 | 9.4 | 10.7 |
| Fluconazole | |||
| Sample 1 | 2.8 | 2.5 | 2.8 |
| Sample 2 | 3.0 | 2.5 | 2.9 |
| Sample 3 | 3.0 | 3.1 | 2.9 |
| Sample 4 | 3.4 | 3.2 | 3.9 |
| Sample 5 | 3.9 | 3.2 | 3.6 |
| Sample 6 | 4.6 | 4.1 | 4.3 |
| Sample 7 | 4.7 | 4.4 | 5.2 |
| Sample 8 | 4.8 | 4.2 | 4.5 |
| Sample 9 | 5.7 | 6.1 | 5.8 |
| Sample 10 | 6.3 | 5.7 | 5.9 |
| Sample 11 | 6.9 | 6.5 | 6.0 |
| Posaconazole | |||
| Sample 1 | 0.2 | 0.1 | 0.1 |
| Sample 2 | 0.8 | 0.6 | 0.6 |
| Sample 3 | 0.8 | 0.7 | 0.8 |
| Sample 4 | 1.0 | 0.8 | 0.9 |
| Sample 5 | 1.1 | 0.8 | 0.9 |
| Sample 6 | 1.3 | 1.3 | 1.3 |
| Sample 7 | 2.1 | 1.8 | 1.8 |
| Sample 8 | 1.8 | 1.6 | |