Table 1.

MIC and MFC values of azole agents for T. asahii isolates tested in time-kill experiments (n = 5)

Agent	MIC or MFCa	MIC (μg/ml) for the indicated isolate at the indicated time
		ATCC 201110		Clinical isolate 1		Clinical isolate 2		Clinical isolate 3		Clinical isolate 4
		24 h	48 h	24 h	48 h	24 h	48 h	24 h	48 h	24 h	48 h
Fluconazole	MIC-2	0.5	4	0.5	0.5	4	16	0.5	2	4	4
	MIC-0	4	4	4	4	16	32	16	16	32	32
	MFC	8	32	16	32	32	64	16	16	64	64
Itraconazole	MIC-2	0.25	0.5	0.12	0.12	0.06	0.25	1	1	0.12	0.12
	MIC-0	1	1	1	1	1	1	2	2	1	2
	MFC	2	2	8	>8	2	2	2	2	4	4
Voriconazole	MIC-2	≤0.015	0.06	≤0.015	0.03	0.06	0.25	0.12	0.25	0.03	0.03
	MIC-0	0.12	0.12	0.06	0.12	0.25	0.5	0.25	0.5	0.5	0.5
	MFC	0.25	0.25	2	2	1	1	2	2	2	2
Posaconazole	MIC-2	0.12	0.12	0.06	0.06	≤0.015	0.5	0.06	0.12	0.25	0.5
	MIC-0	1	1	1	1	1	1	1	2	1	1
	MFC	2	2	2	8	2	2	2	2	2	2
Isavuconazole	MIC-2	≤0.015	≤0.015	≤0.015	0.03	≤0.015	0.12	0.12	0.12	0.25	0.5
	MIC-0	0.5	0.5	0.25	0.5	0.25	0.5	1	1	1	1
	MFC	8	8	2	4	2	2	2	2	2	2

^aMIC-2, reading endpoint which provides ∼50% reduction in turbidity compared to the growth control well; MIC-0, reading endpoint at concentration which provides complete inhibition of growth. MFC, minimum fungicidal concentration.