Table 3.
Time of generation obtained at the MIC and 4× the MIC for each isolate and azole
| Azole | Generation time (h) for the indicated isolate and concna |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| ATCC 201110 |
Clinical isolate 1 |
Clinical isolate 2 |
Clinical isolate 3 |
Clinical isolate 4 |
||||||
| MIC | 4× MIC | MIC | 4× MIC | MIC | 4× MIC | MIC | 4× MIC | MIC | 4× MIC | |
| Fluconazole | 38.62 | Killing | 3 | 34 | >48 | Killing* | 2.6 | 3.3 | 4.8 | 41.8 |
| Itraconazole | 19.95 | Killing | 5.4 | >48 | 4.3 | 12.5 | 7.7 | >48 | 3.1 | 5.7 |
| Voriconazole | 22.31 | Killing | 6.4 | >48 | ND | ND | 13 | Killing | 2.7 | 7.2 |
| Posaconazole | 4.09 | 19.1 | 3.4 | Killing | 3.8 | 33.1 | 2.7 | >48 | 2.5 | >48 |
| Isavuconazole | 3.81 | 3.8 | 2.9 | 8.2 | 2.5 | 3.9 | 2.4 | 4.1 | 3 | Killing |
a
ND, not determined. *, Number of viable cells below starting inoculum.