Fig 4.

Maps of the genomic loci of the CARP genes, RNAi target fragments, and domain annotations. The sequence data are from tritrypdb.org; ORFs are indicated in black. “RNAi screen fragments” were identified as described for Fig. 3C; “RNAi confirmatory fragments” are the target fragments designed for the experiments shown in Fig. 5 and 6. Domain architecture was analyzed using Smart (smart.embl-heidelberg.de/) and Superfamily (supfam.cs.bris.ac.uk). cAMP binding-domain-like, SSF51206; DM10, SM000676; EF hand, SSF47473; TPR-like, SCOP48452. Bar, 100 bp.