Skip to main content
. 2013 Oct;57(10):4861–4871. doi: 10.1128/AAC.00720-13

Table 3.

Alterations of transcription for ΔIP-H5 versus N315ΔIP and N315 rpoB(N967I) versus N315

Function and ORFa Gene Productb Ratio of signal intensity (mutant to parent strain)
ΔIP-H5/N315ΔIP N315rpoB(N967I)/N315
Environmental information processing
    Autolysin-associated genes and regulators
        SA0252 lrgA Holin-like protein; murein hydrolase regulator LrgA 2.53 6.57
        SA0253 lrgB Antiholin-like protein LrgB 2.08 6.60
        SA2327 cidC Regulatory protein for murein hydrolase activity 0.44 0.26
        SA2328 cidB Regulatory protein for murein hydrolase activity 0.48 0.27
        SA2329 cidA Regulatory protein for murein hydrolase activity 0.42 0.25
        SA1898 sceD-like Similar to SceD protein, predicted to be a lytic transglycosylase 2.21 3.26
    Other signal transduction and regulators
        SA2090 rsr Repressor of sarR and agr genes 0.30 0.38
        SA2091 sarY Staphylococcal accessory regulator Y 0.22 0.31
        SA2092 Similar to transcription regulator AraC type regulator 0.20 0.35
Metabolism
    Cell-wall biosynthesis and metabolism
        SA0124 Similar to glycosyltransferase TuaA 0.39 0.43
        SA0125 Similar to exopolysaccharide G (EpsG) 0.35 0.40
        SA0523 Similar to poly(glycerol-phosphate) alpha-glucosyltransferase 2.03 2.33
        SA1964 fmtB (mrp) Cell surface protein; inactivation reduces MET resistance 0.24 0.29
    Cell envelope biogenesis
        SA0126 Similar to capsular polysaccharide synthesis protein 14H 0.39 0.43
        SA0127 Similar to capsular polysaccharide synthesis protein 14L 0.47 0.50
    Carbon hydrate metabolism
    Nitrogen metabolism
    Energy metabolism
    Nucleotide transport and metabolism
        SA1047 pyrF Orotidine-5-phosphate decarboxylase 0.34 0.48
        SA1172 Similar to GMP reductase 0.32 0.47
    Sugar transport and metabolism
        SA0837 Similar to 2-isopropylmalate synthase 2.95 2.86
        SA1991 lacG 6-Phospho-beta-galactosidase 0.29 0.23
        SA1992 lacE PTS system, lactose-specific IIBC component 0.29 0.25
        SA1993 lacF PTS system, lactose-specific IIA component 0.34 0.19
        SA1994 lacD Tagatose-1,6-diphosphate aldolase 0.36 0.21
        SA1995 lacC Tagatose-6-phosphate kinase 0.42 0.21
        SA1996 lacB Galactose-6-phosphate isomerase LacB subunit 0.49 0.25
        SA2486 2-Oxoglutarate/malate translocator homolog 2.13 2.03
    Amino acid transport and metabolism
        SA0822 argG Argininosuccinate synthase 0.40 0.48
        SA0850 Similar to oligopeptide ABC transporter oligopeptide-binding protein 0.27 0.44
    Terpenoid metabolism
        SA1304 Similar to component A of hexaprenyl diphosphate synthase 2.24 2.19
    Secretion and other transport system
        SA0956 Similar to Mn2+ transport protein 0.20 0.32
        SA2203 mdeA Similar to multidrug resistance protein 2.36 2.14
        SA2442 secA2 Preprotein translocase secA homolog 2.31 2.18
        SA2443 asp3 Accessory secretory protein Asp3 3.10 3.20
        SA2444 asp2 Accessory secretory protein Asp2 3.89 3.36
        SA2445 asp1 Accessory secretory protein Asp1 5.93 4.04
        SA2446 secY2 Similar to preprotein translocase secY 5.51 4.01
Genetic information processing
    SA0706 Similar to comF operon protein 3 2.34 3.16
    SA1899 Similar to single-strand DNA binding protein 2.41 2.56
Virulence factor
    SA0393 ssl11 Exotoxin 15 0.31 0.23
    SA0519 sdrC Ser-Asp-rich fibrinogen-binding, bone sialoprotein-binding protein 2.59 3.48
    SA0520 sdrD Ser-Asp-rich fibrinogen-binding, bone sialoprotein-binding protein 2.26 3.45
    SA0521 sdrE Ser-Asp-rich fibrinogen-binding, bone sialoprotein-binding protein 4.45 4.60
    SA1267 ebhA Extracellular matrix-binding protein EbhA 0.22 0.11
    SA1577 sasC S. aureus surface protein C 0.36 0.40
    SA2423 clfB Clumping factor B 4.58 2.49
    SA2430 aur Zinc metalloproteinase aureolysin 0.40 3.50
Hypothetical protein
    SA0262 Hypothetical protein 2.18 2.35
    SA0266 Conserved hypothetical protein 2.17 2.16
    SA0267 Hypothetical protein 2.10 2.21
    SA0268 Hypothetical protein 2.07 2.74
    SA0269 Hypothetical protein 2.00 2.30
    SA0271 Conserved hypothetical protein 2.41 3.90
    SA0275 Conserved hypothetical protein 2.18 2.16
    SA0331 Conserved hypothetical protein 0.31 0.33
    SA0332 Conserved hypothetical protein 0.23 0.35
    SA0333 Conserved hypothetical protein 0.26 0.35
    SA0394 Hypothetical protein 0.30 0.24
    SA0663 Hypothetical protein 0.32 0.48
    SA0737 Hypothetical protein 2.90 2.28
    SA0738 Hypothetical protein 2.55 2.37
    SA0739 Conserved hypothetical protein 2.86 5.11
    SA0741 Conserved hypothetical protein 3.93 4.14
    SA0742 Hypothetical protein 3.74 3.29
    SA0761 Conserved hypothetical protein 2.54 6.06
    SA0830 Conserved hypothetical protein 2.49 2.63
    SA1002 Hypothetical protein 2.40 3.25
    SA1049 Hypothetical protein 0.41 0.37
    SA1222 Hypothetical protein 2.04 2.49
    SA1268 Hypothetical protein 0.36 0.25
    SA1664 Conserved hypothetical protein 2.22 2.23
    SA1755 Hypothetical protein (bacteriophage ϕN315) 0.25 0.188
    SA2299 Conserved hypothetical protein 2.70 2.04
    SA2491 Conserved hypothetical protein 2.49 2.55
a

Locus tags are based on S. aureus strain N315. ORF, open reading frame.

b

MET, methicillin; PTS, phosphotransferase system.