Fig 2.
Efficacies of fluconazole (FLC) and voriconazole (VRC) for Galleria mellonella infected with different strains of Candida tropicalis. Ten larvae per group were infected with 2 × 106 cells of C. tropicalis ATCC 750, CL-6835, or TP-13650. For C. tropicalis ATCC 200956, an inoculum of 4 × 106 cells was used. After inoculation, larvae were treated with 0.8 or 4 μg of VRC/larva (subtherapeutic and therapeutic doses, respectively) or with 0.8, 3.6, or 8 μg of FLC/larva (subtherapeutic and therapeutic doses and twice the therapeutic dose, respectively). An untreated control group was included. Larva survival was monitored daily; the larvae are considered dead when they do not respond to touch.