Table 1.
Admission demographics of patients included in the pharmacokinetic study
| Parameter | Result (range)i for: |
|||
|---|---|---|---|---|
| Artemether/dihydroartemisinin |
Lumefantrine |
Quinine |
||
| Pregnant women (n = 21) | Pregnant women (n = 26) | Nonpregnant women (n = 17) | Pregnant women (n = 23) | |
| Age (yr) | 21 (16–35) | 20 (18–38) | 21 (18–29) | 21 (18–37) |
| Body wt (kg) | 55 (49–88) | 56 (44–74) | 49 (40–63) | 56 (44–71) |
| Gestational age (wk) | 27 (13–36) | 22.5 (16–38) | 26 (13–37) | |
| 2nd trimester (%) | 47.6 | 69.2 | 52.2 | |
| 3rd trimester (%) | 52.4 | 30.8 | 47.8 | |
| Body temp (°C) | 36.7 (36.0–38.5) | 36.7 (36.0–39.3) | 36.7 (36.1–38.2) | 37.1 (36.0–38.9) |
| P. falciparum (parasites/μl) | 1,570 (88.0–148,000) | 638 (32–11,800) | 751 (48–152,190) | 2,160 (39–44,500) |
| Platelets (109/liter) | 167 (64–285) | 185 (83–255)a | 153 (78–247)d | 132 (15–313) |
| Bilirubin (mg/dl) | 0.91 (0.56–5.53) | 0.75 (0.25–2.27)b | 1.41 (0.39–2.80) | 1.30 (0.31–3.36) |
| Hematocrit (%) | 34.0 (23.2–44.5) | 29.5 (20.3–35.0)a | 37.9 (35.0–43.3)d | 31.3 (22.1–39.8) |
| Diastolic blood pressure (mm Hg) | 60.0 (46.0–75.0) | 60.5 (44.0–73.0) | 65.0 (49.0–81.0) | 63.0 (45.0–80.0) |
| Hemoglobin (g/dl) | 11.3 (7.6–14.6) | 10.0 (6.9–12.4)a | 12.8 (11.5–14.5)c | 10.4 (7.4–12.7) |
| Red blood cells (1012/liter) | 3.71 (2.37–4.79) | 3.39 (2.23–4.51)a | 4.28 (3.89–4.81)d | 3.43 (2.37–4.50) |
| Neutrophils (109/liter) | 2.75 (1.14–4.13) | 3.30 (1.89–6.03)e | 2.58 (0.74–4.86)g | 2.47 (0.55–6.53)h |
| Eosinophils (106/liter) | 70 (20–570) | 230 (40–810)f | 280 (110–640)g | 85 (10–300)h |
| Basophils (106/liter) | 20 (10–60) | 20 (10–50)e | 40 (20–160)d | 30 (10–80) |
| Lymphocytes (109/liter) | 1.98 (1.12–3.51) | 1.82 (0.77–3.75)a | 1.34 (0.62–2.99)d | 2.21 (0.69–3.61) |
| Monocytes (109/liter) | 0.55 (0.26–1.00) | 0.31 (0.01–3.02)a | 0.26 (0.02–0.44)d | 0.63 (0.17–1.34) |
| ALATj results (IU/liter) | 14.0 (5.0–35.0) | 16.0 (8.0–86.7)b | 23.0 (7.0–109) | 16.0 (8.0–26.0) |
| Creatinine results (mg/dl) | 0.47 (0.33–0.66) | 0.54 (0.38–0.93)g | 0.71 (0.40–0.96) | 0.49 (0.35–1.29) |
a
Based on results for 17 patients.
b
Based on results for 21 patients.
c
Based on results for 16 patients.
d
Based on results for 13 patients.
e
Based on results for 15 patients.
f
Based on results for 14 patients.
g
Based on results for 10 patients.
h
Based on results for 22 patients.
i
Values are given as the median (range) unless otherwise specified.
j
ALAT, alanine aminotransferase.