Table 2.

Noncompartmental analysis of lumefantrine in pregnant and nonpregnant patients with uncomplicated P. falciparum malaria

Parametera	Result (range)b for:		P value
	Pregnant women (n = 25)	Nonpregnant women (n = 17)
Total dose (mg/kg)	51.4 (38.9–65.5)c	58.8 (45.7–72.0)	0.010
Tmax (h)	4.00 (0.0833–12.1)c	6.00 (1.00–14.0)	0.032
Cmax(μg/ml)	9.19 (0.485–22.4)c	8.88 (4.50–17.0)	0.747
CL/F (liters/h)	4.40 (1.54–36.3)	4.63 (2.46–9.87)	0.828
CL/F (liters/h/kg)	0.0829 (0.0288–0.825)	0.0942 (0.0503–0.224)	0.377
V/F (liters)	414 (63.4–2,510)	421 (227–1,330)	0.450
V/F (liters/kg)	6.90 (1.22–57.1)	7.65 (4.63–30.3)	0.148
T1/2 (h)	53.5 (28.5–79.4)	65.7 (48.2–93.7)	0.003
AUC72–LAST (h · μg/ml)	177 (63.0–1,130)	163 (86.1–4,400)	0.691
AUC72–∞ (h · μg/ml)	189 (64.7–1,170)	197 (99.0–544)	0.949
AUC0–LAST (h · μg/ml)	632 (77.7–1,840)	591 (270–1,080)	0.729
AUC0–∞ (h · μg/ml)	654 (79.4–1,870)	621 (292–1,170)	0.828
AUC0–∞/dose (h · μg/ml/[mg/kg])	12.1 (1.21–34.7)	10.6 (4.46–19.9)	0.377
Day 7 concn (ng/ml)	488 (30.7–3,550)d	720 (339–2,150)	0.128

^aC_max, maximum observed plasma concentration after the last dose; T_{MAX LAST}, observed time after last dose to reach C_max; CL, elimination clearance; V, apparent volume of distribution; T_1/2, terminal elimination half-life; AUC_72–LAST, observed area under the plasma concentration-time curve from 72 h to the last observed concentration; AUC_72–∞, predicted area under the plasma concentration time curve from 72 h to infinity; AUC_0–LAST, observed area under the plasma concentration-time curve from zero time to the last observed concentration; AUC_0–∞, predicted area under the plasma concentration time curve from zero time to infinity; Day 7 concn, observed day 7 concentration after repeated drug administration; F, oral bioavailability.

^bValues are given as the median (range) unless otherwise specified.

^cBased on results for 26 patients.

^dBased on results for 20 patients.