Fig 3.

Baseline susceptibility of NS3 protease domains isolated from patients infected with GT1a or GT1b. EC₅₀ values for faldaprevir (A) and for IFN-α (B) for each baseline sample are shown. Each point represents ≥3 independent in vitro phenotyping experiments. (C) Fold changes of individual EC₅₀ values were calculated relative to an EC₅₀ reference value for wild-type replicons treated with faldaprevir (12 ± 4 nM). Wilcoxon P values are shown. Horizontal lines represent the means. One of 96 patient-derived NS3 chimeric replicons did not replicate in vitro and could not be phenotyped.