Table 3.
Paromomycin concentrations in plasmaa following administration of paromomycin alone or WR 279,396 to children on day 1 and day 20
| Treatment | Parameterb | Value for time point |
|||||
|---|---|---|---|---|---|---|---|
| Day 1 |
Day 1 (−sub 313c) |
Day 20 |
|||||
| 0 h | 4 h | 0 h | 4 h | 0 h | 4 h | ||
| Paromomycin | No. of subjects | 18 | 18 | 18 | 18 | ||
| Mean concn, ng/ml (% CV) | 5.00 (282.9) | 143 (98.7) | 75.7 (424.3) | 693 (424.3) | |||
| GeoMean concn | 1.73 | 94.4 | 51.8 | 505 | |||
| WR 279,396 | No. of subjects | 16 | 16 | 15 | 15 | 16 | 16 |
| Mean concn, ng/ml (% CV) | 38.9 (386.6) | 507 (326.5) | 0.0 (0.0) | 143 (82.2) | 99.0 (133.4) | 880 (98.6) | |
| GeoMean concn | 1.74 | 24.4 | 97.1 | 13.9 | 605 | ||
| P value (WR279,396 vs paromomycin) | 0.333 | 0.999 | 0.514 | 0.466 | |||
a
Plasma concentrations normalized to the average cream dose of 2.81 g.
b
GeoMean, geometric mean.
c
Data for subject no. 313 were omitted.